- Greg Capullo
- Todd McFarlane
- J. Scott Campbell
- Jason Shawn Alexander
- Jerome Opena
- Todd McFarlane
- Tom Orzechowski
- Fco Plascencia
- Brian Haberlin
- Peter Steigerwald
- Matt Hollingsworth
- Jonathan Glapion
- J. Scott Campbell
- Jordan Butler
- Ben Timmreck
- Andy Arias
- There are 24 versions of this issue, including variant covers, additional printings, and exclusives.
- This is cover "Q" (blank), one of 15 covers that were distributed evenly.
- Spawn 300 is the 2nd independent US comic to ever reach issue 300
(after Cerebus).
Spawn's master plan comes to a head as he allows himself to be stripped of his symbiote after drawing out his enemies and finally learning who killed Wanda. Meanwhile, other friends and foes of Spawn undergo metamorphoses of their own.