- There are 23 versions of this issue, including variant covers, additional printings, and exclusives.
- This is the 2nd printing of this issue.
- This "Inaugural Signing Day" Edition was exclusive to a Todd McFarlane signing event on October 26, 2019. Held in Arizona, the event was to commemorate the release of issue 301.
- Limited to 1000 copies.
- The cover is an homage to Amazing Spider-Man 300, also by McFarlane.
- Spawn 301 is the 1st creator-owned US comic to ever reach issue 301.
Spawn reveals new powers to the Violator as he unleashes his master plan. Elsewhere, Spawn's efforts have awakened many other players in the game, as he continues to hunt down agents of Heaven and Hell.